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In vitro assays that rely on the incubation of peripheral lymphoid cells with mycobacterial lysates have evidenced Vγ9Vδ2 T cell expansion is mediated by protease-resistant and pAg. A member of the transmembrane butyrophilin (BTN) proteins was required for the activation of human γδ T cells by microbial or endogenous pAg. Learn more: PAg and γδ T Cells
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